1TL8
Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex
Summary for 1TL8
Entry DOI | 10.2210/pdb1tl8/pdb |
Related | 1K4t |
Descriptor | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TPC)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ... (5 entities in total) |
Functional Keywords | complex (isomerase-dna), dna, topoisomerase i, drug, poison, idenoisoquinoline, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleolus: P11387 |
Total number of polymer chains | 4 |
Total formula weight | 84038.30 |
Authors | Ioanoviciu, A.,Antony, S.,Pommier, Y.,Staker, B.L.,Stewart, L.,Cushman, M. (deposition date: 2004-06-09, release date: 2005-06-21, Last modification date: 2011-07-13) |
Primary citation | Ioanoviciu, A.,Antony, S.,Pommier, Y.,Staker, B.L.,Stewart, L.,Cushman, M. Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis J.Med.Chem., 48:4803-4814, 2005 Cited by PubMed: 16033260DOI: 10.1021/jm050076b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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