1TL8
Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3' | polymer | 10 | 3061.1 | 1 | |||
| 2 | B (C) | 5'-D(*(TPC)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3' | polymer | 12 | 3676.5 | 1 | |||
| 3 | C (D) | 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3' | polymer | 22 | 6730.4 | 1 | |||
| 4 | D (A) | DNA topoisomerase I | polymer | 592 | 70248.0 | 1 | UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) | Homo sapiens (human) | |
| 5 | E (D) | 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM | non-polymer | 322.3 | 1 | Chemie (AI3) |
Sequence modifications
A: 174 - 765 (UniProt: P11387)
| PDB | External Database | Details |
|---|---|---|
| Ptr 723 | Tyr 723 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 83716.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 322.3 | |
| All* | Total formula weight | 84038.3 |
