1T9N

Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II

Summary for 1T9N

Entry DOI	10.2210/pdb1t9n/pdb
Descriptor	Carbonic anhydrase II, ZINC ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	proton shuttle, carbonic anhydrase, metalloenzyme, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29450.53
Authors	Fisher, Z.,Hernandez Prada, J.,Tu, C.K.,Duda, D.,Yoshioka, C.,An, H.,Govindasamy, L.,Silverman, D.N.,McKenna, R. (deposition date: 2004-05-18, release date: 2005-01-25, Last modification date: 2023-08-23)
Primary citation	Fisher, Z.,Hernandez Prada, J.A.,Tu, C.K.,Duda, D.,Yoshioka, C.,An, H.,Govindasamy, L.,Silverman, D.N.,McKenna, R. Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II Biochemistry, 44:1097-1105, 2005 Cited by PubMed: 15667203 DOI: 10.1021/bi0480279 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation