1SKJ

COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX

Summary for 1SKJ

Entry DOI	10.2210/pdb1skj/pdb
Descriptor	PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN, 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID (3 entities in total)
Functional Keywords	tyrosine-protein kinase, v-src sh2 domain, phosphotyrosine recognition domain, pp60 src sh2 domain, peptidomimetic, ureido
Biological source	Rous sarcoma virus
Total number of polymer chains	1
Total formula weight	13479.07
Authors	Holland, D.R.,Rubin, J.R. (deposition date: 1997-09-18, release date: 1998-02-25, Last modification date: 2023-08-09)
Primary citation	Plummer, M.S.,Holland, D.R.,Shahripour, A.,Lunney, E.A.,Fergus, J.H.,Marks, J.S.,McConnell, P.,Mueller, W.T.,Sawyer, T.K. Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40:3719-3725, 1997 Cited by PubMed: 9371236 DOI: 10.1021/jm970402q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation