1SH9

Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease

1SH9 の概要

• エントリーDOI: 10.2210/pdb1sh9/pdb
• 関連するPDBエントリー: 1SGU
• 関連するBIRD辞書のPRD_ID: PRD_001001
• 分子名称: POL polyprotein, RITONAVIR (3 entities in total)
• 機能のキーワード: hiv-1 protease, non-active site mutations, active site mutations, ritonavir, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22392.38

構造登録者

Clemente, J.C.,Moose, R.E.,Hemrajani, R.,Govindasamy, L.,Reutzel, R.,McKenna, R.,Abanje-McKenna, M.,Goodenow, M.M.,Dunn, B.M. (登録日: 2004-02-25, 公開日: 2004-10-05, 最終更新日: 2023-08-23)

• 主引用文献: Clemente, J.C.,Moose, R.E.,Hemrajani, R.,Whitford, L.R.,Govindasamy, L.,Reutzel, R.,McKenna, R.,Agbandje-McKenna, M.,Goodenow, M.M.,Dunn, B.M.; Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease.; Biochemistry, 43:12141-12151, 2004; PubMed: 15379553; DOI: 10.1021/bi049459m

実験手法

X-RAY DIFFRACTION (2.5 Å)