1SH9
Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | POL polyprotein | polymer | 99 | 10835.7 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 | RETROPEPSIN |
| 2 | C (B) | RITONAVIR | non-polymer | 720.9 | 1 | BIRD (PRD_001001) Chemie (RIT) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Arg 20 | Lys 88 | engineered mutation |
| Ile 32 | Val 100 | engineered mutation |
| Phe 33 | Leu 101 | engineered mutation |
| Ile 36 | Met 104 | engineered mutation |
| Val 54 | Ile 122 | engineered mutation |
| Pro 63 | Leu 131 | engineered mutation |
| Val 71 | Ala 139 | engineered mutation |
| Ala 82 | Val 150 | engineered mutation |
| Val 84 | Ile 152 | engineered mutation |
| Met 90 | Leu 158 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21671.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 720.9 | |
| All* | Total formula weight | 22392.4 |
