1SDU

Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.

Summary for 1SDU

Entry DOI	10.2210/pdb1sdu/pdb
Related	1FF0 1SDT 1SDV
Descriptor	protease RETROPEPSIN, SULFATE ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	drug resistance hiv-1 protease, hydrolase
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	2
Total formula weight	22286.33
Authors	Mahalingam, B.,Wang, Y.-F.,Boross, P.I.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2004-02-14, release date: 2004-05-25, Last modification date: 2024-02-14)
Primary citation	Mahalingam, B.,Wang, Y.-F.,Boross, P.I.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site Eur.J.Biochem., 271:1516-1524, 2004 Cited by PubMed: 15066177 DOI: 10.1111/j.1432-1033.2004.04060.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation