1SDU
Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protease RETROPEPSIN | polymer | 99 | 10758.7 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | D (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | E (B) | N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE | non-polymer | 613.8 | 1 | Chemie (MK1) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 75 | variant |
| Ile 33 | Leu 101 | variant |
| Ile 63 | Leu 131 | variant |
| Ala 67 | Cys 135 | variant |
| Met 90 | Leu 158 | variant |
| Ala 95 | Cys 163 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21517.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 768.9 | |
| All* | Total formula weight | 22286.3 |
