1RX3
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
Summary for 1RX3
| Entry DOI | 10.2210/pdb1rx3/pdb |
| Descriptor | DIHYDROFOLATE REDUCTASE, MANGANESE (II) ION, METHOTREXATE, ... (6 entities in total) |
| Functional Keywords | oxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 19351.24 |
| Authors | Sawaya, M.R. (deposition date: 1996-09-19, release date: 1997-01-11, Last modification date: 2024-04-03) |
| Primary citation | Sawaya, M.R.,Kraut, J. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36:586-603, 1997 Cited by PubMed: 9012674DOI: 10.1021/bi962337c PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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