1RX3
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DIHYDROFOLATE REDUCTASE | polymer | 159 | 18020.3 | 1 | UniProt (P0ABQ4) Pfam (PF00186) In PDB | Escherichia coli | DHFR |
2 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
3 | A | METHOTREXATE | non-polymer | 454.4 | 1 | Chemie (MTX) | |||
4 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
5 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
6 | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: P0ABQ4)
PDB | External Database | Details |
---|---|---|
Asp 37 | Asn 37 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 18020.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1330.9 | |
All* | Total formula weight | 19351.2 |