1RPW

Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine

Summary for 1RPW

Entry DOI	10.2210/pdb1rpw/pdb
Related	1JT6 1JTY 1JUS
Descriptor	Transcriptional regulator qacR, SULFATE ION, 4,4'[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE, ... (4 entities in total)
Functional Keywords	qacr hexamidine, transcription
Biological source	Staphylococcus aureus
Total number of polymer chains	4
Total formula weight	90892.28
Authors	Murray, D.S.,Schumacher, M.A.,Brennan, R.G. (deposition date: 2003-12-03, release date: 2004-06-01, Last modification date: 2023-08-23)
Primary citation	Murray, D.S.,Schumacher, M.A.,Brennan, R.G. Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. J.Biol.Chem., 279:14365-14371, 2004 Cited by PubMed: 14726520 DOI: 10.1074/jbc.M313870200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation