1RA8

DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 2-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE

Summary for 1RA8

Entry DOI	10.2210/pdb1ra8/pdb
Descriptor	DIHYDROFOLATE REDUCTASE, FOLIC ACID, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	oxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	18968.90
Authors	Sawaya, M.R.,Kraut, J. (deposition date: 1996-11-21, release date: 1997-03-12, Last modification date: 2023-08-09)
Primary citation	Sawaya, M.R.,Kraut, J. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36:586-603, 1997 Cited by PubMed: 9012674 DOI: 10.1021/bi962337c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation