1QXE

Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds

Summary for 1QXE

• Entry DOI: 10.2210/pdb1qxe/pdb
• Related: 1QXD
• Descriptor: Hemoglobin alpha chain, Hemoglobin beta chain, SULFATE ION, ... (7 entities in total)
• Functional Keywords: allosteric; antisickling; relaxed state; hemoglobin; sickle cell; 5-hydroxymethyl-2-furfural, oxygen storage-transport complex, oxygen storage/transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 65599.71

Authors

Safo, M.K.,Abdulmalik, O.,Danso-Danquah, R.,Nokuri, S.,Joshi, G.S.,Musayev, F.N.,Asakura, T.,Abraham, D.J. (deposition date: 2003-09-05, release date: 2003-09-16, Last modification date: 2023-08-23)

• Primary citation: Safo, M.K.,Abdulmalik, O.,Danso-Danquah, R.,Burnett, J.C.,Nokuri, S.,Joshi, G.S.,Musayev, F.N.,Asakura, T.,Abraham, D.J.; Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds; J.Med.Chem., 47:4665-4676, 2004; PubMed: 15341482; DOI: 10.1021/jm0498001

Experimental method

X-RAY DIFFRACTION (1.85 Å)