1QWH
a covalent dimer of transthyretin that affects the amyloid pathway
Summary for 1QWH
Entry DOI | 10.2210/pdb1qwh/pdb |
Descriptor | Transthyretin (2 entities in total) |
Functional Keywords | thyroid hormone, liver, plasma, cerebrospinal fluid, polyneuropathy, disease mutation, transport, thyroxine, binding protein, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 25716.74 |
Authors | Foss, T.,Kelker, M.S.,Wilson, I.A. (deposition date: 2003-09-02, release date: 2004-09-14, Last modification date: 2023-08-16) |
Primary citation | Foss, T.R.,Kelker, M.S.,Wiseman, R.L.,Wilson, I.A.,Kelly, J.W. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. J.Mol.Biol., 347:841-854, 2005 Cited by PubMed: 15769474DOI: 10.1016/j.jmb.2005.01.050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
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