1Q6K

Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate

Summary for 1Q6K

• Entry DOI: 10.2210/pdb1q6k/pdb
• Descriptor: Cathepsin K, SULFATE ION, TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE, ... (4 entities in total)
• Functional Keywords: cathepsin k, catk, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P43235
• Total number of polymer chains: 1
• Total formula weight: 23860.87

Authors

Catalano, J.G.,Deaton, D.N.,Furfine, E.S.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L. (deposition date: 2003-08-13, release date: 2004-03-16, Last modification date: 2024-10-30)

Primary citation

Catalano, J.G.,Deaton, D.N.,Furfine, E.S.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L.
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors
Bioorg.Med.Chem.Lett., 14:275-278, 2004

PubMed Abstract: The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.

PubMed: 14684342
DOI: 10.1016/j.bmcl.2003.09.088

Experimental method

X-RAY DIFFRACTION (2.1 Å)