1Q4X
Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-24
Summary for 1Q4X
Entry DOI | 10.2210/pdb1q4x/pdb |
Descriptor | Thyroid hormone receptor beta-1, [4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID (3 entities in total) |
Functional Keywords | conformational change in two framework helices upon ligand binding, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10828 |
Total number of polymer chains | 1 |
Total formula weight | 29334.97 |
Authors | Borngraeber, S.,Budny, M.J.,Chiellini, G.,Cunha-Lima, S.T.,Togashi, M.,Webb, P.,Baxter, J.D.,Scanlan, T.S.,Fletterick, R.J. (deposition date: 2003-08-04, release date: 2004-02-03, Last modification date: 2024-04-03) |
Primary citation | Borngraeber, S.,Budny, M.J.,Chiellini, G.,Cunha-Lima, S.T.,Togashi, M.,Webb, P.,Baxter, J.D.,Scanlan, T.S.,Fletterick, R.J. Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc.Natl.Acad.Sci.USA, 100:15358-15363, 2003 Cited by PubMed: 14673100DOI: 10.1073/pnas.2136689100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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