1PVH
Crystal structure of leukemia inhibitory factor in complex with gp130
Summary for 1PVH
Entry DOI | 10.2210/pdb1pvh/pdb |
Descriptor | Interleukin-6 receptor beta chain, Leukemia inhibitory factor, IODIDE ION, ... (4 entities in total) |
Functional Keywords | cytokine, receptor, signaling, beta sheet, four helix bundle, signaling protein-cytokine complex, signaling protein/cytokine |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P40189 Secreted: P15018 |
Total number of polymer chains | 4 |
Total formula weight | 83690.83 |
Authors | Boulanger, M.J.,Bankovich, A.J.,Kortemme, T.,Baker, D.,Garcia, K.C. (deposition date: 2003-06-27, release date: 2003-10-14, Last modification date: 2023-08-16) |
Primary citation | Boulanger, M.J.,Bankovich, A.J.,Kortemme, T.,Baker, D.,Garcia, K.C. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol.Cell, 12:577-589, 2003 Cited by PubMed: 14527405DOI: 10.1016/S1097-2765(03)00365-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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