1PTO
THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING
Summary for 1PTO
| Entry DOI | 10.2210/pdb1pto/pdb |
| Descriptor | PERTUSSIS TOXIN (SUBUNIT S1), PERTUSSIS TOXIN, PERTUSSIS TOXIN (SUBUNIT S4), ... (7 entities in total) |
| Functional Keywords | toxin |
| Biological source | Bordetella pertussis More |
| Cellular location | Secreted: P04978 P04979 P04980 P04981 P04978 |
| Total number of polymer chains | 12 |
| Total formula weight | 212512.46 |
| Authors | Stein, P.E.,Read, R.J. (deposition date: 1994-03-22, release date: 1995-09-15, Last modification date: 2024-10-30) |
| Primary citation | Stein, P.E.,Boodhoo, A.,Armstrong, G.D.,Heerze, L.D.,Cockle, S.A.,Klein, M.H.,Read, R.J. Structure of a pertussis toxin-sugar complex as a model for receptor binding. Nat.Struct.Biol., 1:591-596, 1994 Cited by PubMed Abstract: Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis which is important the pathogenesis of whooping cough and the generation of a protective immune response. The diverse biological activities of the toxin depend on its ability to recognize carbohydrate-containing receptors on a wide variety of eukaryotic cells. We present here the crystal structure of pertussis toxin complexed with a soluble oligosaccharide from transferrin. Binding sites for the terminal sialic acid-galactose moiety are revealed on both subunits S2 and S3 of the B-oligomer. Identification of amino acid residues involved in receptor binding will improve the design of genetically inactivated toxins for use in new acellular whooping cough vaccines. PubMed: 7634099DOI: 10.1038/nsb0994-591 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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