1P8D
X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol
Summary for 1P8D
Entry DOI | 10.2210/pdb1p8d/pdb |
Descriptor | Oxysterols receptor LXR-beta, nuclear receptor coactivator 1 isoform 3, 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL, ... (4 entities in total) |
Functional Keywords | lxr, epoxycholesterol, nuclear receptor, steroid receptor, liver x receptor, transcription, membrane protein-protein binding complex, membrane protein/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P55055 |
Total number of polymer chains | 4 |
Total formula weight | 63875.37 |
Authors | Williams, S.,Bledsoe, R.K.,Collins, J.L.,Boggs, S.,Lambert, M.H.,Miller, A.B.,Moore, J.,McKee, D.D.,Moore, L.,Nichols, J.,Parks, D.,Watson, M.,Wisely, B.,Willson, T.M. (deposition date: 2003-05-06, release date: 2003-07-08, Last modification date: 2024-04-03) |
Primary citation | Williams, S.,Bledsoe, R.K.,Collins, J.L.,Boggs, S.,Lambert, M.H.,Miller, A.B.,Moore, J.,McKee, D.D.,Moore, L.,Nichols, J.,Parks, D.,Watson, M.,Wisely, B.,Willson, T.M. X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch. J.Biol.Chem., 278:27138-27143, 2003 Cited by PubMed: 12736258DOI: 10.1074/jbc.M302260200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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