1P8D
X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Oxysterols receptor LXR-beta | polymer | 250 | 28730.9 | 2 | UniProt (P55055) Pfam (PF00104) In PDB | Homo sapiens (human) | Liver X receptor beta, Nuclear orphan receptor LXR-beta, Ubiquitously-expressed nuclear receptor, Nuclear receptor NER |
| 2 | C, D | nuclear receptor coactivator 1 isoform 3 | polymer | 25 | 2806.2 | 2 | GenBank (22538459) Pfam (PF08832) UniProt (by SIFTS) (Q15788) In PDB | Steroid Receptor Co-activator 1, SRC1 | |
| 3 | A, B | 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL | non-polymer | 400.6 | 2 | Chemie (CO1) | |||
| 4 | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A, B: 214 - 461 (UniProt: P55055)
| PDB | External Database | Details |
|---|---|---|
| Gly 212 | - | cloning artifact |
| Ser 213 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 63074.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 801.3 | |
| All* | Total formula weight | 63875.4 |
