1P8D
X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Oxysterols receptor LXR-beta | polymer | 250 | 28730.9 | 2 | UniProt (P55055) Pfam (PF00104) | Homo sapiens (human) | Liver X receptor beta, Nuclear orphan receptor LXR-beta, Ubiquitously-expressed nuclear receptor, Nuclear receptor NER |
| 2 | C, D (C, D) | nuclear receptor coactivator 1 isoform 3 | polymer | 25 | 2806.2 | 2 | GenBank (22538459) Pfam (PF08832) UniProt (by SIFTS) (Q15788) | Steroid Receptor Co-activator 1, SRC1 | |
| 3 | E, F (A, B) | 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL | non-polymer | 400.6 | 2 | Chemie (CO1) PubChem (16759976) PubChem (20610833) PubChem (44302258) PubChem (50987447) PubChem (56947093) PubChem (9887255) PubChem (10237666) PubChem (10250418) PubChem (3247059) PubChem (15597289) PubChem (15597290) PubChem (16064712) PubChem (126969898) PubChem (126969901) PubChem (142521819) PubChem (146159722) PubChem (171318093) PubChem (162950489) PubChem (168322791) PubChem (169439820) PubChem (174841758) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A, B: 214 - 461 (UniProt: P55055)
| PDB | External Database | Details |
|---|---|---|
| Gly 212 | - | cloning artifact |
| Ser 213 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 63074.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 801.3 | |
| All* | Total formula weight | 63875.4 |
