1OPH
NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN
Summary for 1OPH
Entry DOI | 10.2210/pdb1oph/pdb |
Related | 1EJM 1OO8 1QLP |
Descriptor | Alpha-1-antitrypsin precursor, Trypsinogen, cationic precursor (3 entities in total) |
Functional Keywords | serine proteinase inhibitor, michaelis-like complex, serpin, alpha-1 antitrypsin, trypsin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009 Secreted, extracellular space: P00760 |
Total number of polymer chains | 2 |
Total formula weight | 69704.98 |
Authors | Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G. (deposition date: 2003-03-05, release date: 2003-08-05, Last modification date: 2023-08-16) |
Primary citation | Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G. Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases J.Biol.Chem., 278:37881-37887, 2003 Cited by PubMed: 12860985DOI: 10.1074/jbc.M305195200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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