1OPH

NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Alpha-1-antitrypsin precursor	polymer	394	44276.3	1	UniProt (P01009) Pfam (PF00079) In PDB	Homo sapiens (human)	Alpha-1 protease inhibitor, Alpha-1- antiproteinase, PRO0684/PRO2209
2	B	Trypsinogen, cationic precursor	polymer	243	25428.7	1	UniProt (P00760) Pfam (PF00089) In PDB	Bos taurus (cattle)	Beta-trypsin, Fragment
3		water	water		18.0	377	Chemie (HOH)

Sequence modifications

A: 1 - 394 (UniProt: P01009)

PDB	External Database	Details
Met 1	-	initiating methionine
Leu 51	Phe 75	engineered mutation
Ala 59	Thr 83	engineered mutation
Ala 68	Thr 92	engineered mutation
Gly 70	Ala 94	engineered mutation
Ser 232	Cys 256	engineered mutation
Arg 358	Met 382	engineered mutation
Ile 374	Met 398	engineered mutation
Ala 381	Ser 405	engineered mutation
Arg 387	Lys 411	engineered mutation

B: -4 - 245 (UniProt: P00760)

PDB	External Database	Details
Ala 195	Ser 197	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69705.0
All*	Total formula weight	69705.0

*Water molecules are not included.