1O6H
Squalene-Hopene Cyclase
Summary for 1O6H
Entry DOI | 10.2210/pdb1o6h/pdb |
Related | 1GSZ 1H35 1H36 1H37 1H39 1H3A 1H3B 1H3C 1O6Q 1O6R 1O79 1SQC 1UMP 2SQC 3SQC |
Descriptor | SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-(6-{[1-(4-BROMOPHENYL)ISOQUINOLIN-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE, ... (4 entities in total) |
Functional Keywords | isomerase, cholesterol biosynthesis, inhibitor, oxidosqualene cyclase, monotopic membrane protein |
Biological source | ALICYCLOBACILLUS ACIDOCALDARIUS |
Total number of polymer chains | 3 |
Total formula weight | 217229.68 |
Authors | Lenhart, A.,Reinert, D.J.,Weihofen, W.A.,Aebi, J.D.,Dehmlow, H.,Morand, O.H.,Schulz, G.E. (deposition date: 2002-10-03, release date: 2003-10-02, Last modification date: 2024-05-08) |
Primary citation | Lenhart, A.,Reinert, D.J.,Aebi, J.D.,Dehmlow, H.,Morand, O.H.,Schulz, G.E. Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase J.Med.Chem., 46:2083-, 2003 Cited by PubMed: 12747780DOI: 10.1021/JM0211218 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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