1NKO

Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7

Summary for 1NKO

• Entry DOI: 10.2210/pdb1nko/pdb
• Descriptor: Sialic acid binding Ig-like lectin 7 (1 entity in total)
• Functional Keywords: immunoglobulin, siglec7, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: Q9Y286
• Total number of polymer chains: 1
• Total formula weight: 15263.00

Authors

Dimasi, N.,Attril, H.,van Aalten, D.M.F.,Moretta, L.,Biassoni, R.,Mariuzza, R.A. (deposition date: 2003-01-03, release date: 2003-04-01, Last modification date: 2024-11-20)

Primary citation

Dimasi, N.,Moretta, A.,Moretta, L.,Biassoni, R.,Mariuzza, R.A.
Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.
Acta Crystallogr.,Sect.D, 60:401-403, 2004

PubMed Abstract: The high-resolution crystal structure of the functional N-terminal domain from the extracellular region of the human natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7 has been determined at 1.45 A resolution; it was obtained from a crystal belonging to a primitive monoclinic space group, with unit-cell parameters a = 32.65, b = 49.72, c = 39.79 A, alpha = gamma = 90, beta = 113 degrees. The structure reported here belongs to a different space group than the previously described Siglec-7 structure and was obtained using a bacterial expression system. The structure unveils the fine structural requirements adopted by a natural killer cell inhibitory receptor of the Siglec family in target-cell recognition and binding.

PubMed: 14747738
DOI: 10.1107/S0907444903028439

Experimental method

X-RAY DIFFRACTION (1.45 Å)