1N46
CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC
Summary for 1N46
Entry DOI | 10.2210/pdb1n46/pdb |
Descriptor | Thyroid hormone receptor Beta-1, [4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-3,5-DIMETHYL-PHENYL]-6-AZAURACIL (3 entities in total) |
Functional Keywords | transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10828 |
Total number of polymer chains | 2 |
Total formula weight | 59040.34 |
Authors | Dow, R.L.,Schneider, S.R.,Paight, E.S.,Hank, R.F.,Chiang, P.,Cornelius, P.,Lee, E.,Newsome, W.P.,Swick, A.G.,Spitzer, J.,Hargrove, D.M.,Patterson, T.A.,Pandit, J.,Chrunyk, B.A.,LeMotte, P.K.,Danley, D.E.,Rosner, M.H.,Ammirati, M.J.,Simons, S.P.,Schulte, G.K.,Tate, B.F.,DaSilva-Jardine, P. (deposition date: 2002-10-30, release date: 2003-04-22, Last modification date: 2024-02-14) |
Primary citation | Dow, R.L.,Schneider, S.R.,Paight, E.S.,Hank, R.F.,Chiang, P.,Cornelius, P.,Lee, E.,Newsome, W.P.,Swick, A.G.,Spitzer, J.,Hargrove, D.M.,Patterson, T.A.,Pandit, J.,Chrunyk, B.A.,LeMotte, P.K.,Danley, D.E.,Rosner, M.H.,Ammirati, M.J.,Simons, S.P.,Schulte, G.K.,Tate, B.F.,DaSilva-Jardine, P. Discovery of a Novel Series of 6-Azauracil-Based Thyroid Hormone Receptor Ligands: Potent, TRbeta Subtype-Selective Thyromimetics Bioorg.Med.Chem.Lett., 13:379-382, 2003 Cited by PubMed: 12565933DOI: 10.1016/S0960-894X(02)00947-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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