1N3I
Crystal Structure of Mycobacterium tuberculosis PNP with transition state analog DADMe-ImmH
Summary for 1N3I
Entry DOI | 10.2210/pdb1n3i/pdb |
Related | 1G2O |
Descriptor | Purine Nucleoside Phosphorylase, PHOSPHATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, ... (4 entities in total) |
Functional Keywords | transition state complex, trimer, pnp, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 3 |
Total formula weight | 83879.15 |
Authors | Lewandowicz, A.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Basso, L.A.,Santos, D.S.,Almo, S.C.,Schramm, V.L. (deposition date: 2002-10-28, release date: 2003-09-30, Last modification date: 2023-10-25) |
Primary citation | Lewandowicz, A.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Basso, L.A.,Santos, D.S.,Almo, S.C.,Schramm, V.L. Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase BIOCHEMISTRY, 42:6057-6066, 2003 Cited by PubMed: 12755607DOI: 10.1021/bi0343830 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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