1L6Z

CRYSTAL STRUCTURE OF MURINE CEACAM1A[1,4]: A CORONAVIRUS RECEPTOR AND CELL ADHESION MOLECULE IN THE CEA FAMILY

Summary for 1L6Z

• Entry DOI: 10.2210/pdb1l6z/pdb
• Related: 1E4J 1HNF
• Descriptor: biliary glycoprotein C, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: ig-like domain, cea family, coronavirus receptor, cell adhesion
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 1
• Total formula weight: 25783.86

Authors

Tan, K.,Zelus, B.D.,Meijers, R.,Liu, J.-H.,Bergelson, J.M.,Duke, N.,Zhang, R.,Joachimiak, A.,Holmes, K.V.,Wang, J.-H. (deposition date: 2002-03-14, release date: 2002-09-14, Last modification date: 2024-10-16)

Primary citation

Tan, K.,Zelus, B.D.,Meijers, R.,Liu, J.-H.,Bergelson, J.M.,Duke, N.,Zhang, R.,Joachimiak, A.,Holmes, K.V.,Wang, J.-H.
CRYSTAL STRUCTURE OF MURINE sCEACAM1a[1,4]: A CORONAVIRUS RECEPTOR IN THE CEA FAMILY
Embo J., 21:2076-2086, 2002

PubMed Abstract: CEACAM1 is a member of the carcinoembryonic antigen (CEA) family. Isoforms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus. Here we report the crystal structure of soluble murine sCEACAM1a[1,4], which is composed of two Ig-like domains and has MHV neutralizing activity. Its N-terminal domain has a uniquely folded CC' loop that encompasses key virus-binding residues. This is the first atomic structure of any member of the CEA family, and provides a prototypic architecture for functional exploration of CEA family members. We discuss the structural basis of virus receptor activities of murine CEACAM1 proteins, binding of Neisseria to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members.

PubMed: 11980704
DOI: 10.1093/emboj/21.9.2076

Experimental method

X-RAY DIFFRACTION (3.32 Å)