1JKX
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase
Summary for 1JKX
| Entry DOI | 10.2210/pdb1jkx/pdb |
| Descriptor | PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE, N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE (3 entities in total) |
| Functional Keywords | purine biosynthesis, anti-cancer agent, enzyme-assembled multisubstrate adduct inhibitor complex, transferase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 4 |
| Total formula weight | 96075.50 |
| Authors | Greasley, S.E.,Marsilje, T.H.,Cai, H.,Baker, S.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A. (deposition date: 2001-07-13, release date: 2001-11-30, Last modification date: 2024-03-13) |
| Primary citation | Greasley, S.E.,Marsilje, T.H.,Cai, H.,Baker, S.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A. Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase. Biochemistry, 40:13538-13547, 2001 Cited by PubMed: 11695901DOI: 10.1021/bi011482+ PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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