1JKX

Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE	polymer	212	23266.3	4	UniProt (P08179) Pfam (PF00551)	Escherichia coli	Glycinamide Ribonucleotide Transformylase; GART; GAR TRANSFORMYLASE; 5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE
2	E, F, G, H (A, B, C, D)	N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE	non-polymer		752.6	4	Chemie (138)
3	I, J, K, L (A, B, C, D)	water	water		18.0	607	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	93065.0
Non-Polymers*	Number of molecules	4
	Total formula weight	3010.5
All*	Total formula weight	96075.5

*Water molecules are not included.