1J4R

FK506 BINDING PROTEIN COMPLEXED WITH FKB-001

Summary for 1J4R

Entry DOI	10.2210/pdb1j4r/pdb
Descriptor	FK506-BINDING PROTEIN, 1-[2,2-DIFLUORO-2-(3,4,5-TRIMETHOXY-PHENYL)-ACETYL]-PIPERIDINE-2-CARBOXYLIC ACID 4-PHENYL-1-(3-PYRIDIN-3-YL-PROPYL)-BUTYL ESTER, GLYCEROL, ... (5 entities in total)
Functional Keywords	rotamase, inhibitor, isomerase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol : P62942
Total number of polymer chains	3
Total formula weight	37667.89
Authors	Sheriff, S. (deposition date: 2001-10-29, release date: 2001-12-19, Last modification date: 2023-08-16)
Primary citation	Dubowchik, G.M.,Vrudhula, V.M.,Dasgupta, B.,Ditta, J.,Chen, T.,Sheriff, S.,Sipman, K.,Witmer, M.,Tredup, J.,Vyas, D.M.,Verdoorn, T.A.,Bollini, S.,Vinitsky, A. 2-Aryl-2,2-difluoroacetamide FKBP12 ligands: synthesis and X-ray structural studies. Org.Lett., 3:3987-3990, 2001 Cited by PubMed: 11735566 DOI: 10.1021/ol0166909 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation