1IRA
COMPLEX OF THE INTERLEUKIN-1 RECEPTOR WITH THE INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL1RA)
Summary for 1IRA
Entry DOI | 10.2210/pdb1ira/pdb |
Descriptor | INTERLEUKIN-1 RECEPTOR ANTAGONIST, INTERLEUKIN-1 RECEPTOR, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | cytokine receptor, receptor antagonist, immunoglobulin fold, complex (cytokine receptor-antagonist), complex (cytokine receptor-antagonist) complex, complex (cytokine receptor/antagonist) |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm: P18510 Membrane ; Single-pass type I membrane protein : P14778 |
Total number of polymer chains | 2 |
Total formula weight | 54771.97 |
Authors | Schreuder, H.A.,Tardif, C.,Tramp-Kalmeyer, S.,Soffientini, A.,Sarubbi, E.,Akeson, A.,Bowlin, T.,Yanofsky, S.,Barrett, R.W. (deposition date: 1998-04-09, release date: 1998-06-17, Last modification date: 2023-08-09) |
Primary citation | Schreuder, H.,Tardif, C.,Trump-Kallmeyer, S.,Soffientini, A.,Sarubbi, E.,Akeson, A.,Bowlin, T.,Yanofsky, S.,Barrett, R.W. A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. Nature, 386:194-200, 1997 Cited by PubMed: 9062194DOI: 10.1038/386194a0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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