1HWR
MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS
Summary for 1HWR
Entry DOI | 10.2210/pdb1hwr/pdb |
Descriptor | HIV-1 PROTEASE, [4-R-(4-ALPHA,6-BETA,7-BETA]-HEXAHYDRO-5,6-DI(HYDROXY)-1,3-DI(ALLYL)-4,7-BISPHENYLMETHYL)-2H-1,3-DIAZEPINONE (2 entities in total) |
Functional Keywords | aspartyl protease, hydrolase, acid proteinase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 |
Total number of polymer chains | 2 |
Total formula weight | 21921.85 |
Authors | Chang, C.-H. (deposition date: 1998-03-20, release date: 1999-03-23, Last modification date: 2024-05-22) |
Primary citation | Ala, P.J.,DeLoskey, R.J.,Huston, E.E.,Jadhav, P.K.,Lam, P.Y.,Eyermann, C.J.,Hodge, C.N.,Schadt, M.C.,Lewandowski, F.A.,Weber, P.C.,McCabe, D.D.,Duke, J.L.,Chang, C.H. Molecular recognition of cyclic urea HIV-1 protease inhibitors. J.Biol.Chem., 273:12325-12331, 1998 Cited by PubMed: 9575185DOI: 10.1074/jbc.273.20.12325 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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