1HOS

INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS

Summary for 1HOS

• Entry DOI: 10.2210/pdb1hos/pdb
• Descriptor: HIV-1 PROTEASE, (2-PHENYL-1-CARBOBENZYL-OXYVALYL-AMINO)-ETHYL-PHOSPHINIC ACID (3 entities in total)
• Functional Keywords: hydrolase(acid proteinase)
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• Total number of polymer chains: 2
• Total formula weight: 22378.36

Authors

Abdel-Meguid, S.,Zhao, B. (deposition date: 1993-04-06, release date: 1993-10-31, Last modification date: 2024-02-07)

• Primary citation: Abdel-Meguid, S.S.,Zhao, B.,Murthy, K.H.,Winborne, E.,Choi, J.K.,DesJarlais, R.L.,Minnich, M.D.,Culp, J.S.,Debouck, C.,Tomaszek Jr., T.A.,Meek, T.D.,Dreyer, G.B.; Inhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate. Synthesis and crystallographic analysis.; Biochemistry, 32:7972-7980, 1993; PubMed: 8347601; DOI: 10.1021/bi00082a019

Experimental method

X-RAY DIFFRACTION (2.3 Å)