1HOS

INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS

Experimental procedure

Spacegroup name	P 61
Unit cell lengths	63.200, 63.200, 83.400
Unit cell angles	90.00, 90.00, 120.00

Refinement procedure

Resolution	6.000 - 2.300
R-factor	0.186 *
Rwork	0.186
RMSD bond length	0.017
RMSD bond angle	3.620
Refinement software	X-PLOR

Data quality characteristics

	Overall
Low resolution limit [Å]	9999.000 *
High resolution limit [Å]	2.300 *
Rmerge	0.073 *
Total number of observations	41859 *
Number of reflections	8213 *
Completeness [%]	97.0 *

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	Vapor diffusion, hanging drop *	5 *

Crystallization Reagents in Literatures

ID	crystal ID	solution	reagent name	concentration (unit)	details
1	1	reservoir	ammonium sulfate	18-26 (%sat)
2	1	reservoir	acetate	200 (mM)