1HLF
BINDING OF GLUCOPYRANOSYLIDENE-SPIRO-THIOHYDANTOIN TO GLYCOGEN PHOSPHORYLASE B: KINETIC AND CRYSTALLOGRAPHIC STUD
Summary for 1HLF
Entry DOI | 10.2210/pdb1hlf/pdb |
Related | 1GGN |
Descriptor | GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE, (5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one, ... (4 entities in total) |
Functional Keywords | transferase, glycogen phosphorylase, inhibitor complex, catalytic site, design |
Biological source | Oryctolagus cuniculus (rabbit) |
Total number of polymer chains | 1 |
Total formula weight | 97802.60 |
Authors | Oikonomakos, N.G.,Skamnaki, V.T.,Docsa, T.,Toth, B.,Gergely, P.,Osz, E.,Szilagyi, L.,Somsak, L. (deposition date: 2000-12-01, release date: 2000-12-13, Last modification date: 2023-08-09) |
Primary citation | Oikonomakos, N.G.,Skamnaki, V.T.,Osz, E.,Szilagyi, L.,Somsak, L.,Docsa, T.,Toth, B.,Gergely, P. Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B BIOORG.MED.CHEM., 10:261-268, 2002 Cited by PubMed: 11741774DOI: 10.1016/S0968-0896(01)00277-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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