1GPZ

THE CRYSTAL STRUCTURE OF THE ZYMOGEN CATALYTIC DOMAIN OF COMPLEMENT PROTEASE C1R

Summary for 1GPZ

Entry DOI	10.2210/pdb1gpz/pdb
Related	1APQ 1ELV
Descriptor	COMPLEMENT C1R COMPONENT, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	hydrolase, activation, complement, innate immunity, modular structure, serine protease
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	92347.03
Authors	Budayova-Spano, M.,Fontecilla-Camps, J.C.,Gaboriaud, C. (deposition date: 2001-11-15, release date: 2002-07-31, Last modification date: 2023-12-13)
Primary citation	Budayova-Spano, M.,Lacroix, M.,Thielens, N.,Arlaud, G.,Fontecilla-Camps, J.C.,Gaboriaud, C. The Crystal Structure of the Zymogen Catalytic Domain of Complement Protease C1R Reveals that a Disruptive Mechanical Stress is Required to Trigger Activation of the C1 Complex. Embo J., 21:231-, 2002 Cited by PubMed: 11823416 DOI: 10.1093/EMBOJ/21.3.231 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation