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1GHQ

CR2-C3D COMPLEX STRUCTURE

Summary for 1GHQ
Entry DOI10.2210/pdb1ghq/pdb
DescriptorCOMPLEMENT C3, CR2/CD121/C3D/EPSTEIN-BARR VIRUS RECEPTOR, ZINC ION, ... (5 entities in total)
Functional Keywordscr2, c3d, immune system-viral protein receptor complex, immune system/viral protein receptor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted: P01024
Membrane; Single-pass type I membrane protein: P20023
Total number of polymer chains3
Total formula weight64491.46
Authors
Szakonyi, G.,Guthridge, J.M.,Li, D.,Holers, V.M.,Chen, X.S. (deposition date: 2001-01-11, release date: 2001-06-13, Last modification date: 2024-11-20)
Primary citationSzakonyi, G.,Guthridge, J.M.,Li, D.,Young, K.,Holers, V.M.,Chen, X.S.
Structure of complement receptor 2 in complex with its C3d ligand.
Science, 292:1725-1728, 2001
Cited by
PubMed Abstract: Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.
PubMed: 11387479
DOI: 10.1126/science.1059118
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.04 Å)
Structure validation

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