1FYR

DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX

Summary for 1FYR

Entry DOI	10.2210/pdb1fyr/pdb
Descriptor	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, HEPATOCYTE GROWTH FACTOR RECEPTOR PEPTIDE (3 entities in total)
Functional Keywords	grb2, sh2 domain, phosphopeptide, met, domain swapping, dimerization, hormone-growth factor complex, hormone/growth factor
Biological source	Homo sapiens (human) More
Cellular location	Golgi apparatus (By similarity): P29354 Membrane; Single-pass type I membrane protein: P08581
Total number of polymer chains	8
Total formula weight	55522.44
Authors	Schiering, N.,Casale, E.,Caccia, P.,Giordano, P.,Battistini, C. (deposition date: 2000-10-03, release date: 2000-12-06, Last modification date: 2023-11-15)
Primary citation	Schiering, N.,Casale, E.,Caccia, P.,Giordano, P.,Battistini, C. Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex. Biochemistry, 39:13376-13382, 2000 Cited by PubMed: 11063574 DOI: 10.1021/bi0012336 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation