1EAS

NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OF ORALLY ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES

Summary for 1EAS

Entry DOI	10.2210/pdb1eas/pdb
Descriptor	PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	hydrolase (serine protease)
Biological source	Sus scrofa (pig)
Cellular location	Secreted: P00772
Total number of polymer chains	1
Total formula weight	26727.69
Authors	Ceccarelli, C. (deposition date: 1994-11-22, release date: 1995-02-07, Last modification date: 2012-02-22)
Primary citation	Bernstein, P.R.,Andisik, D.,Bradley, P.K.,Bryant, C.B.,Ceccarelli, C.,Damewood Jr., J.R.,Earley, R.,Edwards, P.D.,Feeney, S.,Gomes, B.C.,Kosmider, B.J.,Steelman, G.B.,Thomas, R.M.,Vacek, E.P.,Veale, C.A.,Williams, J.C.,Wolanin, D.J.,Woolson, J.A. Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones. J.Med.Chem., 37:3313-3326, 1994 Cited by PubMed: 7932559 DOI: 10.1021/jm00046a016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation