1DXW

structure of hetero complex of non structural protein (NS) of hepatitis C virus (HCV) and synthetic peptidic compound

Summary for 1DXW

• Entry DOI: 10.2210/pdb1dxw/pdb
• Related: 1BT7
• NMR Information: BMRB: 4617
• Related PRD ID: PRD_000426
• Descriptor: SERINE PROTEASE, N-(tert-butoxycarbonyl)-L-alpha-glutamyl-N-[(1R)-1-(carboxycarbonyl)-3,3-difluoropropyl]-L-leucinamide, ZINC ION (3 entities in total)
• Functional Keywords: non structural protein, hepatitis c virus, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: HEPATITIS C VIRUS (HCV)
• Total number of polymer chains: 1
• Total formula weight: 20209.44

Authors

Barbato, G.,Cicero, D.O.,Cordier, F.,Narjes, F.,Gerlach, B.,Sambucini, S.,Grzesiek, S.,Matassa, V.G.,Defrancesco, R.,Bazzo, R. (deposition date: 2000-01-17, release date: 2001-01-12, Last modification date: 2020-01-15)

• Primary citation: Barbato, G.,Cicero, D.O.,Cordier, F.,Narjes, F.,Gerlach, B.,Sambucini, S.,Grzesiek, S.,Matassa, V.G.,Defrancesco, R.,Bazzo, R.; Inhibitor Binding Induces Active Site Stabilisation of the Hcv Ns3 Protein Serine Protease Domain; Embo J., 19:1195-, 2000; PubMed: 10716920; DOI: 10.1093/EMBOJ/19.6.1195

Experimental method

SOLUTION NMR