1BZY
HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR
Summary for 1BZY
Entry DOI | 10.2210/pdb1bzy/pdb |
Descriptor | HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER, ... (5 entities in total) |
Functional Keywords | phosphoribosyltransferase, immucillin, lesch-nyhan, hgprt, transition state, magnesium, pyrophosphate, oxocarbenium ion, neighboring group participation |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00492 |
Total number of polymer chains | 4 |
Total formula weight | 100268.14 |
Authors | Shi, W.,Li, C.,Tyler, P.C.,Furneaux, R.H.,Grubmeyer, C.,Schramm, V.L.,Almo, S.C. (deposition date: 1998-11-05, release date: 1999-06-22, Last modification date: 2024-05-22) |
Primary citation | Shi, W.,Li, C.M.,Tyler, P.C.,Furneaux, R.H.,Grubmeyer, C.,Schramm, V.L.,Almo, S.C. The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor. Nat.Struct.Biol., 6:588-593, 1999 Cited by PubMed: 10360366DOI: 10.1038/9376 PDB entries with the same primary citation |
Experimental method |
Structure validation
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