1BQO
DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS
Summary for 1BQO
Entry DOI | 10.2210/pdb1bqo/pdb |
Descriptor | STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | stromelysin, matrix metalloprotease, osteoarthritis, structure-based drug design, metalloprotease |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P08254 |
Total number of polymer chains | 2 |
Total formula weight | 39848.75 |
Authors | Pikul, S.,Dunham, K.L.M.,Almstead, N.G.,De, B.,Natchus, M.G.,Anastasio, M.V.,Mcphail, S.J.,Snider, C.E.,Taiwo, Y.O.,Rydel, T.J.,Dunaway, C.M.,Gu, F.,Mieling, G.E. (deposition date: 1998-08-17, release date: 1999-08-17, Last modification date: 2024-02-07) |
Primary citation | Pikul, S.,McDow Dunham, K.L.,Almstead, N.G.,De, B.,Natchus, M.G.,Anastasio, M.V.,McPhail, S.J.,Snider, C.E.,Taiwo, Y.O.,Rydel, T.,Dunaway, C.M.,Gu, F.,Mieling, G.E. Discovery of potent, achiral matrix metalloproteinase inhibitors. J.Med.Chem., 41:3568-3571, 1998 Cited by PubMed: 9733482DOI: 10.1021/jm980253r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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