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1BQO

DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
B0004222molecular_functionmetalloendopeptidase activity
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0031012cellular_componentextracellular matrix
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 301
ChainResidue
AHIS201
AHIS205
AHIS211
BTHR255

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 302
ChainResidue
AHIS151
AASP153
AHIS166
AHIS179

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 303
ChainResidue
AGLY159
AGLY161
AVAL163
AASP181
AGLU184
AASP158

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 304
ChainResidue
AASP107
AASP182
AGLU184
AHOH342

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 305
ChainResidue
AASP141
AGLY173
AASN175
AASP177
AHOH314

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 301
ChainResidue
BHIS201
BHIS205
BHIS211
BN25401

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 302
ChainResidue
BHIS151
BASP153
BHIS166
BHIS179

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 303
ChainResidue
BASP158
BGLY159
BGLY161
BVAL163
BASP181
BGLU184

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA B 304
ChainResidue
BASP107
BASP182
BGLU184
BHOH409

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 305
ChainResidue
BASP141
BGLY173
BASN175
BASP177
BHOH402

site_idBC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE N25 B 401
ChainResidue
BASN162
BVAL163
BLEU164
BALA165
BHIS166
BVAL198
BHIS201
BGLU202
BHIS205
BHIS211
BZN301

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL
ChainResidueDetails
AVAL198-LEU207

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues32
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8740360","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AMET219
AGLU202

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
BMET219
BGLU202

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AGLU202

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
BGLU202

site_idMCSA1
Number of Residues4
DetailsM-CSA 591
ChainResidueDetails
AHIS201metal ligand
AGLU202proton acceptor, proton donor
AHIS205metal ligand
AHIS211metal ligand

site_idMCSA2
Number of Residues4
DetailsM-CSA 591
ChainResidueDetails
BHIS201metal ligand
BGLU202proton acceptor, proton donor
BHIS205metal ligand
BHIS211metal ligand

239149

PDB entries from 2025-07-23

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