1B3N
BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.
Summary for 1B3N
Entry DOI | 10.2210/pdb1b3n/pdb |
Descriptor | PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2), (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE (3 entities in total) |
Functional Keywords | condensing enzymes, fatty acid elongation, cerulenin inhibition, lipid metabolism, drug design, drug target |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 43183.72 |
Authors | Moche, M.,Schneider, G.,Edwards, P.,Dehesh, K.,Lindqvist, Y. (deposition date: 1998-12-14, release date: 1999-04-06, Last modification date: 2024-10-16) |
Primary citation | Moche, M.,Schneider, G.,Edwards, P.,Dehesh, K.,Lindqvist, Y. Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase. J.Biol.Chem., 274:6031-6034, 1999 Cited by PubMed: 10037680DOI: 10.1074/jbc.274.10.6031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
Download full validation report