1AQB
RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA
Summary for 1AQB
| Entry DOI | 10.2210/pdb1aqb/pdb |
| Descriptor | RETINOL-BINDING PROTEIN, CADMIUM ION, RETINOL, ... (4 entities in total) |
| Functional Keywords | retinol transport, retinoids, vitamin a, cadmium ion |
| Biological source | Sus scrofa domestica (domestic pig) |
| Cellular location | Secreted : P27485 |
| Total number of polymer chains | 1 |
| Total formula weight | 21582.52 |
| Authors | Zanotti, G.,Panzalorto, M.,Marcato, A.,Malpeli, G.,Folli, C.,Berni, R. (deposition date: 1997-07-28, release date: 1998-01-28, Last modification date: 2024-11-20) |
| Primary citation | Zanotti, G.,Panzalorto, M.,Marcato, A.,Malpeli, G.,Folli, C.,Berni, R. Structure of pig plasma retinol-binding protein at 1.65 A resolution. Acta Crystallogr.,Sect.D, 54:1049-1052, 1998 Cited by PubMed Abstract: The crystal structure of pig plasma retinol-binding protein (RBP) has been determined at 1.65 A resolution. The space group is P212121, with a = 45.81 (4), b = 53.14 (5), c = 72.97 (8) A and one protein molecule in the asymmetric unit. The structure has been solved using the molecular replacement method and refined with restrained least squares to an R factor of 0.1844 and an Rfree of 0.237 for 18 874 and 1001 independent reflections, respectively. The relatively high resolution structure of pig holoRBP has revealed some new structural details. Moreover, it has provided a description of the binding site for Cd2+, a metal ion which is required for protein crystallization. The hepta-coordination of the RBP-bound cadmium ion involves different residues of two symmetry-related RBP molecules, consistent with the participation of the cation in intermolecular interactions that in turn promote protein crystallization. PubMed: 9757135DOI: 10.1107/S0907444998002303 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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