190D

Crystal structure of a four-stranded intercalated DNA: d(C4)

Summary for 190D

• Entry DOI: 10.2210/pdb190d/pdb
• Descriptor: DNA (5'-D(*CP*CP*CP*C)-3') (2 entities in total)
• Functional Keywords: u-dna, quadruple helix, parallel-stranded tetraplex, base intercalated, mismatched, dna
• Total number of polymer chains: 8
• Total formula weight: 8894.16

Authors

Chen, L.,Cai, L.,Zhang, X.,Rich, A. (deposition date: 1994-09-02, release date: 1995-02-07, Last modification date: 2024-02-07)

Primary citation

Chen, L.,Cai, L.,Zhang, X.,Rich, A.
Crystal structure of a four-stranded intercalated DNA: d(C4).
Biochemistry, 33:13540-13546, 1994

PubMed Abstract: The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.

PubMed: 7947764
DOI: 10.1021/bi00250a005

Experimental method

X-RAY DIFFRACTION (1.8 Å)