185D

SEQUENCE SPECIFICITY OF QUINOXALINE ANTIBIOTICS. 1. SOLUTION STRUCTURE OF A 1:1 COMPLEX BETWEEN TRIOSTIN A AND [D(GACGTC)]2 AND COMPARISON WITH THE SOLUTION STRUCTURE OF THE [N-MECYS3, N-MECYS7]TANDEM-[D(GATATC)]2 COMPLEX

Summary for 185D

Related193D 1PFE 1VS2 1XVK 1XVN 1XVR 2ADW 2DA8 3GO3
Related PRD IDPRD_000488
DescriptorTRIOSTIN A, DNA (5'-D(*GP*AP*CP*GP*TP*C)-3'), 2-CARBOXYQUINOXALINE (3 entities in total)
Functional Keywordsbisintercalator, depsipeptide, quinoxaline, antibiotic, antitumor, dna-antibiotic complex, dna/antibiotic
Biological sourceSTREPTOMYCINEAE
Total number of polymer chains3
Total molecular weight4761.73
Authors
Addess, K.J.,Feigon, J. (deposition date: 1994-08-10, release date: 1995-02-07, Last modification date: 2017-11-01)
Primary citation
Addess, K.J.,Feigon, J.
Sequence Specificity of Quinoxaline Antibiotics. 1. Solution Structure of a 1:1 Complex between Triostin a and [D(Gacgtc)]2 and Comparison with the Solution Structure of the [N-Mecys3,N-Mecys7]Tandem-[D(Gatatc)]2 Complex.
Biochemistry, 33:12386-, 1994
PubMed: 7918461 (PDB entries with the same primary citation)
DOI: 10.1021/BI00207A005
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliers210MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures