13GK

CDK2 in complex with INCB125496

This is a non-PDB format compatible entry.

Summary for 13GK

• Entry DOI: 10.2210/pdb13gk/pdb
• Descriptor: Cyclin-dependent kinase 2, GLYCEROL, 4-[(1M)-1-{4-[(azetidin-1-yl)methyl]-2-chlorophenyl}-1H-imidazol-4-yl]-N-[1-(methanesulfonyl)piperidin-4-yl]-5-(trifluoromethyl)pyrimidin-2-amine, ... (5 entities in total)
• Functional Keywords: cdk2, serine/threonine kinase, cell cycle regulation, aminopyrimidine, inhibitor, transferase, transferase-inhibitor complex
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 34850.85

Authors

Epling, L.B.,Fenalti, F. (deposition date: 2026-05-05, release date: 2026-09-30)

• Primary citation: Mukai, K.,Smith, B.R.,Ye, Q.,Epling, L.B.,Lai, C.,Huo, L.,Bowen, S.,Drake, K.,Kennedy, K.,Boer, J.,Zimmer, D.,Zhang, W.,Hansbury, M.J.,Chand, S.,Li, J.,Zhang, G.,Stump, K.,Lo, Y.,Favata, M.,Yang, G.,Covington, M.,Deller, M.C.,Macarron, R.,Jackson, J.,Mayes, P.,Kim, S.,Wang, X.,Hummel, J.R.,Yao, W.; Discovery of INCB127443: A Potent and Orally Available Inhibitor of Cyclin-Dependent Kinase 2; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c01506

Experimental method

X-RAY DIFFRACTION (1.44 Å)