13GH

IST1 bound to PI(3,5)P2 containing membrane

Summary for 13GH

Entry DOI	10.2210/pdb13gh/pdb
Related	13GJ 13GM
EMDB information	77057
Descriptor	IST1 homolog, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (3 entities in total)
Functional Keywords	escrt, escrt-iii, pip2, pi(3, 5)p2, endosomal, cytokinesis, lipid binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22320.85
Authors	Moss III, F.R.,Talledge, N.,Alian, A.,McCullough, J.,Frost, A.,Sundquist, W.I. (deposition date: 2026-05-05, release date: 2026-07-08)
Primary citation	Alian, A.,McCullough, J.,Moss III, F.R.,Talledge, N.,Mohammed, A.,Gerstner, C.,Dalluge, J.,Paine, E.,Davulcu, O.,Chang, C.L.,Frost, A.,Sundquist, W.I. Phosphatidylinositol Diphosphate Binding by ESCRT-III Filaments Proc.Natl.Acad.Sci.USA, 2026 Cited by DOI: 10.1073/pnas.2616668123 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.56 Å)

Structure validation