13CW

Crystal structure of covalent inhibitor 3-(2-chloroacetamido)-N-(m-tolyl)benzamide bound to Ubiquitin C-terminal Hydrolase-L3

This is a non-PDB format compatible entry.

Summary for 13CW

• Entry DOI: 10.2210/pdb13cw/pdb
• Descriptor: Ubiquitin carboxyl-terminal hydrolase isozyme L3, 3-(2-chloroacetamido)-N-(3-methylphenyl)benzamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: uchl3, covalent inhibitor, chloroacetamide, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 109492.96

Authors

Pannala, N.,Patel, R.,Flaherty, D.,Das, C. (deposition date: 2026-04-30, release date: 2026-08-26)

• Primary citation: Beeralingappa, N.C.,Lu, M.,Patel, R.,Pannala, N.,Dhiman, A.,Heil, B.N.,Imhoff, R.D.,Smith, E.G.,Bahler, M.B.,Marsden, H.L.,Allen-Petersen, B.L.,Wendt, M.K.,Das, C.,Flaherty, D.P.; Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3; Biorxiv, 2026; DOI: 10.64898/2026.05.26.727856

Experimental method

X-RAY DIFFRACTION (2.48 Å)